pharmacounty

medicinal chemistry

2009-04-01T19:42:00.001-07:00

medicinal chemistry

mass spectroscopy in drug discovery

Book Description: )

Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improvingthe performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effectivepharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.

http://rapidshare.com/files/1887 ... _Drug_Discovery.rar

Medicinal Chemistry

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes
Springer | 408 pages | 2008-10-01 | ISBN: 1402068441 | PDF | 6.4 Mb

Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks.
Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances.
In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications.

link:-http://depositfiles.com/en/files/7925821

Methods and Principles in Medicinal Chemistry: Microwaves in Organic and Medicinal Chemistry

Wiley-VCH | 2005-11-04 | ISBN: 3527312102 | 422 pages | PDF | 2,4 Mb

The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and the IUPAC. In this handy source of information for any practicing synthetic chemist they focus on common reaction types in medicinal chemistry, including solid-phase and combinatorial methods. They consider the underlying theory, latest developments in microwave applications and include a variety of examples from recent literature, as well as less common applications that are equally relevant for organic and medicinal chemists. An indispensable reference for researchers with an affinity to modern methods.

http://depositfiles.com/files/5392278

Medicinal Chemistry: A Molecular and Biochemical Approach

ISBN: 0195104560
Title: Medicinal Chemistry: A Molecular and Biochemical Approach
Author: Thomas Nogrady, Donald F. Weaver
Publisher: Oxford University Press, USA (2005)
Publication Date: 2005-07-28
Number Of Pages: 672
Average Amazon Rating: 5.0
Book Id 35280
Editorial Description
Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design.

http://rapidshare.com/files/100180/Medicinal_Chemistry_-_A_Molecular_and_Biochemical_Approach.pdf

Pharmacophores and Pharmacophore Searches (Methods andPrinciples in Medicinal Chemistry)
Wiley-VCH | ISBN: 3527312501 | 2006-10-27 | PDF | 395 pages | 5.63 Mb | RS

This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research. Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties. With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.

http://rapidshare.com/files/46800269/Pharmacophores_and_Pharmacophore_Searches.pdf

Burger's Medicinal Chemistry and Drug Discovery, 6 Volume Set

This new sixth edition of Burger's Medicinal Chemistry and Drug Discovery offers several new and unique features. For the first time, an online version of this major reference work will offer updated content from the print edition and easy access. For the first time, all volumes are structured entirely according to content and published simultaneously to provide broad coverage of medicinal chemistry and drug discovery for new or experienced medicinal chemists, biologists, pharmacologists and molecular biologists. This includes a current and global perspective of drug design, and drug development.

With expanded content from 69 chapters to over 100 chapters, this sixth edition of Burger's Medicinal Chemistry and Drug Discovery includes more than 50ew material. An entire section has been dedicated to cancer research. Areas included are those at the foreground of life science including:
* Proteomics
* Genomics
* Bioinformatics
* Combinatorial Chemistry
* High-Throughput Screening
* Blood Substitutes
* Allosteric Effectors as Potential Drugs
* COX Inhibitors
* Statins
* High-Throughput Pharmacology
* and More.

The new sixth edition of Burger's Medicinal Chemistry and Drug Discovery is a Memorial Edition to Professor Alfred Burger who published this major reference work in the first edition as "Medicinal Chemistry" in two volumes in 1951. Dr. Burger's research focused on analgesics, antidepressants and chemotherapeutic agents. He is one of the few academicians to have a drug, designed and synthesized in his laboratories and brought to market. Dr. Burger's contribution to the fields of medicinal chemistry and drug discovery are well renowned and documented. He received the Louis Pasteur Medal of the Pasteur Institute and the American Chemical Society Smissman Award.
link:-http://rapidshare.com/files/151414911/BMCDD6V_.part1.rar
http://rapidshare.com/files/151400676/BMCDD6V_.part2.rar

pharmacopeia

2009-04-01T19:38:00.000-07:00

pharmacopeia

Indian Pharmacopoeia 1996

DETAILS

ISBN: 8190065831

Place of Publication: New Delhi

Publisher: The Controller of Publications

Edition: 1st ed.

Year of Publication: 2003

Physical Description: 140p.

Book Format: Hardcover

Language: English

SYNOPSIS

The latest edition of the Indian Pharmacopoeia was published in 1996. It was updated by additions and amendments introduced through addendum 2000. Under the Drugs and Cosmetics Act, 1940, the Indian Pharmacopoeia is the legally recognised book of standards for the quality of drug substances and their preparations included therein. In view of the rapid developments is pharmaceutical sciences and technology, it became necessary to make further changes in the existing compendium. Addendum 2002 amends as well as adds new drugs and preparations to the Indian pharmacopoeia 1996 with a view to keeping the pharmacopoeia updated to the extent possible. Besides amending the existing monographs and appendices, it contains 19 new monographs including monographs of 12 antiretroviral drugs and 7 formulations of these substances. A new appendix on residual solvents has been incorporated. Some monographs have undergone major amendments. The appendix on high performance liquid chromatography has been replaced with a new version which also includes the ion chromatography. The Addendum 2002 is a companion volume to the Indian pharmacopoeia which is indispensable for all concerned with the quality of drugs.

http://rapidshare.com/files/40907679/IP_by_www.w5awarez.com.part1.rar
http://rapidshare.com/files/40944572/IP_by_www.w5awarez.com.part2.rar
http://rapidshare.com/files/40949229/IP_by_www.w5awarez.com.part3.rar

Password of RAR File is : www.w5awarez.com

USP NF 2007 (United States Pharmacopeia/National Formulary)

The United States Pharmacopeia is a compendium of quality control tests for drugs and excipients to be introduced into a medicinal formulation. It is published every year [1] by the United States Pharmacopoeial Convention. It forms the basis of enforcement actions by the U.S. Food and Drug Administration and the U.S. Drug Enforcement Administration and is the official pharmacopoeia of the U.S.A. and many other nations. Therefore, in case of a dispute, those methods for, amongst others, identification, assay and purity determination of a drug substance or excipient which are stated in the USP will be the legally binding ones.

Within the field the compendium is referred to simply as the USP. The initials USP are affixed to materials' names to indicate that they conform to the specifications in the USP and may be used medicinally.

DOWNLOAD HERE:

http://rapidshare.com/files/41539644/USP30-NF25.rar

British National Formulary 52

Download Link:

http://rapidshare.com/files/43383934/BNF-52.rar

The International Pharmacopoeia, Third Edition

Presents an historical account of the Pharmacopoeia and describes methods and procedures for the quality control of pharmaceutical substances and dosage forms, including a special section on quality control of anti-malarials.
Download Link:

http://rapidshare.com/files/119989696/Int_pharma3Ed.zip

Japanese Pharmacopoeia (Jp Xiv) (Pharmacopoeia of Japan)

Publisher: Society of Japanese Pharmac
Number Of Pages: 1357
Publication Date: 2002-01
Sales Rank: 3114417
ISBN / ASIN: 4840806721
EAN: 9784840806725
Binding: Hardcover
Manufacturer: Society of Japanese Pharmac
Studio: Society of Japanese Pharmac

Download Link:

http://rapidshare.com/files/63351404/Japanese_Pharmacopoeia14.zip

British Pharmacopoeia 2007

The British Pharmacopoeia (BP) 2007 is the authoritative, current collection of standards for UK medicinal substances and the official source of all UK quality standards. It is an essential reference for anyone involved in pharmaceutical Research & Development, manufacturing and testing, and plays a vital role in ensuring that all medicinal substances on the UK market meet standards of safety, quality and efficacy.

The BP is supplied in a variety of formats designed for ease of use and a wide range of applications. The hard copy edition package contains a boxed five volume set with a separate Veterinary volume, a CD-ROM and access to a comprehensible, regularly updated website. Both the CD-ROM and online formats are easy to network for access across your organisation.

There will not be an edition of the BP entitled 'British Pharmacopoeia 2006'. In order to improve the alignment of the published edition with the effective date of its contents, the forthcoming edition is entitled 'British Pharmacopoeia 2007'.

Key features:

Extensive Revisions including 30 new BP texts
New Supplementary Chapters containing general guidance on Unlicensed Medicines and Method Validation
First BP monograph for Traditional Chinese Medicines
All European Pharmacopoeia 5th edition material up to and including Supplement 5.5 integrated into the text of BP 2007
Value-for-money networking with full technical support from the publishers
CD-ROM and website deliver the complete text of the British Pharmacopoeia, British Approved Names and European Pharmacopoeia standards directly to your PC

Download Links:

http://rapidshare.com/files/54222262/BP2007.part1.rar
http://rapidshare.com/files/54240964/BP2007.part2.rar
http://rapidshare.com/files/54382014/BP2007.part3.rar
http://rapidshare.com/files/54383084/BP2007.part4.rar

British National Formulary (BNF) 54: September 2007

Compiled with the advice of clinical experts, this essential reference provides up-to-date guidance on prescribing, dispensing and administering medicines. The BNF details medicines prescribed in the UK, with special reference to their uses, cautions, contraindications, side-effects, dosage and relative costs. Updated in print every six months, the BNF reflects current best practice as well as legal and professional guidelines relating to the use of medicines The BNF is also available online as part of Medicines Complete, on PDA and on also CD-ROM for intranets.

Download Link:

http://rapidshare.com/files/92295931/BNF-54.zip

European Pharmacopoeia, 4th edition

The European Pharmacopoeia is a single reference work for the quality control of medicines in Europe. Several legal texts make the European Pharmacopoeia mandatory:A Convention on the Elaboration of a European Pharmacopoeia ratified in 2003 by 31 European countries and the European Union; European Union directives 2001/83/EC and 2001/82/EC,on medicines for human use and for veterinary use, respectively, maintain the mandatory character of European Pharmacopoeia specifications on medicines as regards their qualitative and quantitative composition and the tests to be carried out on these medicines, the raw materials used in production and the intermediates of synthesis. All producers of medicines or substances for pharmaceutical use therefore must apply the quality standards of the European Pharmacopoeia for the marketing and use of these products in Europe. The texts of the European Pharmacopoeia are legally binding and compliance is enforced by the administrative or juridical authorities. The national authorities of the member states are bound to apply them if necessary replacing any national monograph on the same subject.

The 4th Edition consists of an initial volume 2002 (4.0) and a collection of 8 non-cumulative supplements (4.1) published three times a year following the decisions of each session of the European Pharmacopoeia Commission. With supplement 4.6, the 4th Edition comprises 1750 specific monographs, 285 general methods illustrated by figures or chromatograms and 2140 reagents. Every 4 months a new volume enters into force.
link:-http://rapidshare.com/files/149869347/CDEP4ed.zip

pharmacology

2009-04-01T04:22:00.000-07:00

Human Drug Metabolism: An Introduction

Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long-term effects it has on the body.Â It is an area of rapid advancement, which brings together the fields of pharmacy, pharmacology and medicine.

This new text provides a concise, user-friendly introduction to drug metabolism that is ideal for undergraduates. Focusing on a conceptual understandingÂ of the drug metabolism system, the book illustrates the basic mechanisms on how xenobiotics are detected, chemically modified and then eliminated from human systems.

http://pt-support.blogspot.com/2009/01/thumdrgmetaintrozip.html

Medical Pharmacology at a Glance, 4th Edition

"Medical Pharmacology at a Glance" is one of the most renowned undergraduate texts in the field of medical pharmacology. Following on from the success of the previous three editions, Professor Michael Neal, one of the great teachers of medical pharmacology, has extensively revised and updated the fourth edition to take account of the rapid developments in the field. This incredibly useful book summarises the core principles of the mode of action of drugs and puts this information within the context of body systems and specific clinical problems. The author discusses the mechanisms of action of each drug, indicating the therapeutics of choice for specific conditions. "Medical Pharmacology at a Glance" follows the now familiar, easy-to-use double page spread format of the at a Glance series. Each section contains a clear illustration depicting the major drugs and their interaction within a particular body system and a concise account of the topic. Key features of the fourth edition include: new material on anti-platelet drugs in the cardiovascular section; new section on immunological drugs; new material on general anaesthetic and anti-viral drugs; and the use of Recommended International Non-proprietary Names (rINN) for drugs. "Medical Pharmacology at a Glance" is ideal for pharmacology revision and for use during clinical placements. It is an essential buy for medical students and scientists requiring a succinct and lucid account of medical pharmacology.

http://pt-support.blogspot.com/2008/12/tmedpharmacoaagzip.html

Pharmacology

This highly acclaimed textbook is a worldwide bestseller, recognized for its emphasis on the mechanisms by which drugs act at the cellular and molecular levels and how that relates to their overall pharmacological effects and clinical uses. The 5th Edition includes four new chapters, a reorganized and expanded section on treatments for infections and cancer, and thorough updates throughout that explore new treatments and advances in molecular biology that may lead to future therapeutic options for cancer, HIV infection, osteoporosis, neurodegenerative disorders, erectile dysfunction, obesity, diabetes, atherosclerosis, cardiac failure, and more. User-friendly features include new chapter overviews reviews of relevant physiology and biochemistry boxed key points and clinical uses references and reading lists a new full-color art program and new "small print" sections that separate the more complex material from the main discussion thread in each chapter, leaving the depth of coverage to the reader's discretion.

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Goodman & Gilman's The Pharmacological Basis of Therapeutics

The undisputed leader in medical pharmacology, without equal. Updated to reflect all critical new developments in drug action and drug-disease interaction. This is the “desert island” book of all medical pharmacology—if you can own just one pharmacology book, this is it.

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medical books

2009-04-01T04:07:00.000-07:00

1)Harrison Internal medicine 17th Edition:-

http://www.egydoctors.net//download/Internal-Medicine/Harrison17ed/Harrison%27s%20Principles%20of%20Internal%20Medicine%2017ed.rar

2)Netter Atlas of Physiology

http://rapidshare.com/files/90806170/netter_atlas_of_physiology.rar

3)Netter Atlas – Anatomy

http://rapidshare.com/files/91403416/Netters_atlas_anatomy.rar

4)Guyton & hall’s Physiology- 11th edition

http://rapidshare.com/files/97010999/Guyton.pdf

5)Robbins Pahological Basis of Diseases-8th Edition:

Here is the Robbin’s Pathology, the latest edition

Extract it only after downloading all the 3 parts

http://rapidshare.com/files/99986628/RobinsBasicPatho-8th_edi.part1.rar

http://rapidshare.com/files/100001770/RobinsBasicPatho-8th_edi.part2.rar

http://rapidshare.com/files/100010642/RobinsBasicPatho-8th_edi.part3.rar